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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Elevated TSH Levels Despite Taking Levothyroxine?

Hello. I am 80 years old and have been on thyroid meds for hypothyroidism since I was about 21. Through the years it has been adjusted. Recently I had a lab test on my TSH. It was 10.330 and was supposed to be 0.450-4.500. My doctor put me on a dosage of 125MCG Levothyroxin. I know he is doing the right thing, but I don t understand why I am taking thyroid if I have a high number already. Could you please explain this to me ? Thank You. Beverly Anderson YYYY@YYYY
Mon, 18 Jun 2018
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Endocrinologist 's  Response

Hello and welcome to ‘Ask A Doctor’ service.
I have reviewed your query and here is my advice.

The TSH level in your blood reveals how much T4 your pituitary gland is asking your thyroid gland to make.
The elevated TSH result means Hypothyroidism or underactive thyroid.

The most common cause of hypothyroidism is Hashimoto's thyroiditis.
In my opinion ,this is your exact diagnosis.

In Hashimoto's thyroiditis, the body mounts an immune reaction against its own thyroid gland tissue, leading to inflammation and the destruction of the gland (thyroiditis).

So,your TSH level is high because your Pituitary gland is asking your thyroid gland to make more Thyroid hormones ,but the inflammated thyroid can not produce hormone any more and it is vital to take the thyroid hormone replacement therapy.

In your circumstances the Hypothyroidism is the result of the insufficient dosis of thyroid hormone replacement therapy or Levothyroxine.

The result means that you need to adjust the actual dosis of Levothyroxine.
The increased dosis of Levothyroxine will help you to normalise your TSH result and feel better.

Hope i have clarified your doubt.
Let me know if i can assist you further.




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What Causes Elevated TSH Levels Despite Taking Levothyroxine?

Hello and welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. The TSH level in your blood reveals how much T4 your pituitary gland is asking your thyroid gland to make. The elevated TSH result means Hypothyroidism or underactive thyroid. The most common cause of hypothyroidism is Hashimoto s thyroiditis. In my opinion ,this is your exact diagnosis. In Hashimoto s thyroiditis, the body mounts an immune reaction against its own thyroid gland tissue, leading to inflammation and the destruction of the gland (thyroiditis). So,your TSH level is high because your Pituitary gland is asking your thyroid gland to make more Thyroid hormones ,but the inflammated thyroid can not produce hormone any more and it is vital to take the thyroid hormone replacement therapy. In your circumstances the Hypothyroidism is the result of the insufficient dosis of thyroid hormone replacement therapy or Levothyroxine. The result means that you need to adjust the actual dosis of Levothyroxine. The increased dosis of Levothyroxine will help you to normalise your TSH result and feel better. Hope i have clarified your doubt. Let me know if i can assist you further.