Since 3.5 weeks I notice fasciculation in my calves and when I run or workout or randomly some very very mild cramps. I get also twitches all over in tights , biceps triceps , eye, temple but they are rare and go away. Actions I took ( given I ve been diagnosed withGeneralized Anxiety Disorder 2 months ago ) : 1st week : went to see 1st neurologist which dismissed ALS/MND from the beginning based on a quick clinical exam 2nd week: Saw a board neurologist with 50 years o experience is his field which he dismissed ALS as well and he didn t even considered necessary to have an EMG 3rd week: Finally found a neuro-muscular specialist with 10 years of experience which agreed to do an EMG in 3 limbs ( Legs, Right hand ) and a nerve conduction study. What he told me ( still waiting for a final report yet ): 1. No evidence of MND , he clearly stated on a white paper for me to be re-assured 2. He suspects a lumbar radiculopathy ( I do have some pain around L4-L5 ) 3. A pinched ulnar nerve ( light ) in the right elbow ( according ncs ) which doesn t bother me. 4. 3rd clinical exam without any clinical weakness or athrophy noticed by all doctors. The reason I am experiencing this anxiety is that my DAD died of ALS in 2003. Mom mentioned that a neurologist made a genetic test for me and he found that I have no predisposition. Dad was sporadic and nobody from it s family had any neuro diseases in the past ( He has 2 sisters and 1 brother ). Grandparents were ok. Last doctor said no EMG is required for follow up, but if I can do a spine MRI ( no contrast ) In 3 months would be good. So, finally my questions are. ( Being 30 years old ). (Condensing) 1. Could EMG miss ALS/PLS or any MND ? If it can, what Is the chance? ( found 2,3 cases on the internet with people which claimed they started with fascics and then weakness ). 2. Could EMG study misdiagnose? How it gets the radiculopathy ? F or H waves? No evidence of MND means that the MUAP was around good values? 3. I am still anxious but I really need a host answer, would this generate me ALS in the early future ? 4. What do you think I should do ? CK blood tests? Should I do a spintal tap ? I want to be assured or not, this anxiety is killing me. 5. Could EMG miss PLS ? I heard some cases. 6. Radiculopathy should show denervation? It s there any chance I could be diagnosed wrongly? What do you think I should go do in the near future and what to search from now on?