Three months following complete knee replacement surgery I developed a heavy, blistered rash aroundthe incision area. Itching was bad, so I used Cortisone to calm the area. Nothing helped. I went to myDR who couldn t find the cause of the rash. She put me on Benedryl, Prednisone and Ranitidine (Zantac).My P.T. ofc. looked at rash and had no answers either, but had me alternate heat then ice packs on rash while I elevated my knee. My DR said this is not a reaction to metal in the knee, but a chemical reactionto some cream I used on my knee. Rash is only on my knee and is probably a 10-inch long oval shapedirritated area.I used Jergens Lotion, Urea 20% Cream prior to rash appearing. The day before the itching began I useda packet from my daughter s DR especially used for joint pain/arthritis. It was strong, and I wonder if that is the culprit. What do you think?