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Taking DOTS medication. Difficulty discharging urine. Side effect of Rcinex?

Sir, I have been under the medication DOTS since October 2012 and continued (i) streptomycin Inj, (ii) Pyrazinamide , (iii)Refampin+ Isoniazid for two months and thereafter Refampin+Isoniazid tablets regularly till date. I have been experiencing difficulties in discharge of urine which turned very slow, insufficient associated with need of pressure and certain irritation in the urinary track. Will you please let me know as to whether this is a side effect of RCniex? With regards
Asked On : Thu, 21 Mar 2013
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Pulmonologist 's  Response
Hi gaurisankar,

Thanks for visiting HCM.

Let me assure you that rifampicin do not cause urinary tract irritation. It usually cause orange coloured urine which is due to metabolite of drug passing in the urine, and is harmless.

Your symptoms may be a problem with prostate like benign prostatic hyperplasia or it's just simple urinary tract infection...both of which has nothing to do with rifampicin or isoniazide which you are taking.

I advise you to go for urine examination (routine microscopy and culture and sensitivity) and ultrasonography of abdomen to look for prostate. And above all continue with your anti tubercular treatment.

Consult your doctor with above reports.

Best wishes
Answered: Wed, 24 Apr 2013
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Internal Medicine Specialist Dr. Pankaj Malhan's  Response
your symptoms looks like an infection of the urinary tract,go get your urine tested for it,you may need some antibiotics to clear it.
rcinex has rifampicin and isoniazid,rifampicin can cause discoloration of urine but urinary infections are not the side effect of these medications.
Answered: Fri, 22 Mar 2013
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