Hello, Muscle fatigue, lethargy, sleep disturbance etc. are common in anxiety disorder. I here feel that Buspar will no longer help you. This is the time for changing the drug. There are drugs available which are more effective then Buspar like SSRI antidepressants which are approved for all type of anxiety disorders. In my patient, I would have given paroxetine because of it s sedating property. If anxiety is very severe then initially anxiolytics can be taken, most commonly low dose benzodiazepines like Klonopin. Was the onset of anxiety related to starting DHEA and any other drugs? You can discuss this with your treating doctor and get proper treatment. Your anxiety will be easily controlled with the drugs mentioned above. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Ivan R. Rommstein, General Surgeon