I am transplant kidney recipient and am immunosuppressed . I had a pneumonia shot 2years ago which attacked my 3rd valve in my heart and started to reject my kidney ,and I am still a working on a long recovery. Main problem now is bp medication I have tried all 4 categories of meds and had no luck with any lots of side effects . I have been on bisoprolol hydraralazine minoxidil since jan Now extreme short of breath fatigue all of the symptoms. No good Also prior to the shot I was on novasc for 11years and had some swelling in the legs I tried Novasc again after the heart failure but the symptoms were even worse with swelling up to the Thighs. Diuretics did not work well as I was up a3-4 times-a night and not urinating properly during the day. I I have been on azathioprmine,methaldopa, norvasc in the past 2years and nothing has been tolerated properly. From jan of last year to nov I had severe bladder infection and had to be on antibiotics for bladder infection. Maybe that is a reason why The meds did not work. I do not know. Today the specialist tells me there is no other blood pressure pills In the 4 categories as I have tried them all and have had too many side effects or it did not lower my BP. I have to find one to live with, either with side effects such as major headaches brain fog, severe edema, tingling shakes etc. ahhhhhh I have lived without my own kidneys for 40 years now been on dialysis and have had 2 transplants. Now I need to find a bp pill and live with the side effect but I do not know which med to take, I am on cyclosporine,I urbane, prednisone Any suggestions would be greatly appreciated. Thank you.