I started Seroquel 6 1/2 months ago and was taking 600mg by the end of 2nd month. I continue taking Adderall 20mg x3 and 2mg Xanax a day. We discontinued use of Lamictal 400mg shortly after starting Seraquel . After a series of side effects, I began decreasing the dosage, currently at 400mg, my doctor is fine with it. I have developed cysts in both breasts, 2 large cysts in one which will be drained. These cysts were not evident 3 months ago. I was having severe muscle and joint pain and rigidity to the point I couldn t move in the morning without severe shooting pains. The pain has lessened a great deal since I have decreased the dosage. Confusion and memory loss increased, EEG and MRI show my brain is clear of tumors, etc. as with other side effects, decrease in dosage has shown decrease in memory loss and confusion. However a cyst on the jaw has shown up. Seraquel, while at first seemed the miracle drug we were looking for has turned out to have brought on a host of medical problems. How quickly/safely can I continue to decrease and discontinue use without bringing on a host of withdrawal effects? My body/brain chemistry reacts/adjusts to medication very quickly. Medication also quits working quickly and I find myself on high dosages. Diagnosis of Bipolar NOS has never been set in stone, nor ADD. Every bipolar med I have been on never worked. For whatever reason Adderall has helped though my doctor doesn t think I have ADD, but a mood disorder. Anti-depressants make me manic. It all started after taking Zoloft for a number of years at a high dosage for long standing major depression (different doc). With all the medications I have been on, none of them have caused physical problems like those I have encountered in such a short time on the Seraquel. This medication seems to be quite toxic to my system.