Hi! thanks for sharing your son s long-standing and severe health problem with us! In such cases of chronic non-healing or non-responding osteomyelitis, especially affecting the lower portions of legs, when a child visits me, I usually consider following things: 1. any injury to skin or loss of skin/soft tissue is dangerous! 2. microbiological culture/sensitivity report is essential to kill the offending organisms 3. chronic infection of bone leads to bone death which is irreversible 4. in long-standing cases tuberculosis, fungus and other unusual infection also take place 5. left untreated, the disease is self progressive that means it spreads quickly to adjacent areas/bones 6. months of antibiotic often fails to heal it and surgery is then must to prevent further loss Therefore, in my opinion, in your son s case, at least partial surgical debridement would be helpful if not an amputation! Hope got the answer; anyways, Also don t forget to write to us in case any more queries. Wishing your son good health!