Hi Pain right after surgery is usually due to injury to the skin or muscles. It may be treated with mild pain relievers such as ibuprofen (such as Advil or Motrin) or acetaminophen (Tylenol). Although you can get these medications without a prescription, check with your provider before taking them as they may interfere with chemotherapy or other treatment. There may be other medical reasons you should not take them. For more severe pain, your provider may prescribe opioids (such as hydrocodone or oxycodone). There are many non-drug methods of easing pain. These include physical therapy, acupuncture, relaxation techniques, massage therapy, hot and cold therapy, yoga and guided imagery.