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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suffering From UTI. Prescribed Augmentin And Dosage Increased. After Urine Test Prescribed Niftran. Advise?

Hi Doctor, I am a male and suffering from the UTI . Doctor prescribed me Augmentin625 for initially 5 days and then increased it to 7-10 days. After 7 days course i was asked to go for Urine test( routine). I did that and the report is showing normal. But as doctor prescribed for ten days i am continuing the medicine for another 3 days.Today after showing the report to doctor he prescribed me Niftran100 mg for ten days. I am in doubt whether i should continue both the medicines or should i stop Augmentin? The doctor is not in town and could not be contacted. please reply.
Fri, 5 Jul 2013
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Internal Medicine Specialist 's  Response
Hi,
Thanks for using Healthcaremagic,
You are suffering from Urinary tract Infection and treated by antibiotic. Please continue to take prescribed antibiotic even if your urine report is not showing any pus cell.
In case of UTI it is better to get a sensitivity test as you are responding to therapy the drug is working.
Take your antibiotic as adviced by your doctor continue to take both the drugs and continue Niftran for 10 days.
Take plenty of fluids to keep urinary trat flushed to prevent recurrence.
Take care.
Good Luck.
Dr.Akhilesh Dubey M.D.
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General & Family Physician Dr. Vishal Vadgama's  Response
Hello,

Thank you for using Healthcaremagic,

Augmentin 625 (amoxicillin 500 mg + Clavulanic acid 125 mg) is effective against that types of bacterias (like Escherichia coli, Klebsiella, Proteus, Staphylococcal aureus, Streptococci etc.) which are most common cause for urinary track infection. According to treatment guidelines, one can take Augmentin 625, two or three times a day for 7 days for the treatment of uncomplicated urinary track infection. This is in accordance to your urine report which became normal on day 7, so this concludes the treatment, no further need of any medicine provided that you have taken medicine strictly as described by the physician and no loner have any other symptoms/ physical problems including burning or pain during urination or decreased urine flow. If you have missed 2 or more doses during these 7 days, than you can take the Augmentin 625 for another 3 days.

While coming to Niftran 100, it contains Nitrofurantoin, which is also active against the bacterias (like Enterobacter, Klebsiella, Proteus etc) which are already covered by Augmentin 625. In addition, consumption of nitrofurantoin in older age is associated with some probable serious side effects like pulmonary fibrosis and drug-induced autoimmune hepatitis. So, according to my perspective, you should not take Niftran 100.

Hope this will help you.

-Dr. Vishal Vadgama (MD)

References:-
1. Goemaere NN, Grijm K, van Hal PT, den Bakker MA (2008). "Nitrofurantoin-induced pulmonary fibrosis: a case report". J Med Case Reports 2: 169. doi:10.1186/1752-1947-2-169. PMC 2408600. PMID 18495029.
2. Björnsson, E; Talwalkar, J; Treeprasertsuk, S; Kamath, PS; Takahashi, N; Sanderson, S; Neuhauser, M; Lindor, K (June 2010). "Drug-induced autoimmune hepatitis: clinical characteristics and prognosis.". Hepatology (Baltimore, Md.)
3. GlaxoSmithKline. Augmentin. Medicine datasheet. 2009. Available from: www.medsafe.govt.nz (Accessed Aug, 2011).
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Suffering From UTI. Prescribed Augmentin And Dosage Increased. After Urine Test Prescribed Niftran. Advise?

Hi, Thanks for using Healthcaremagic, You are suffering from Urinary tract Infection and treated by antibiotic. Please continue to take prescribed antibiotic even if your urine report is not showing any pus cell. In case of UTI it is better to get a sensitivity test as you are responding to therapy the drug is working. Take your antibiotic as adviced by your doctor continue to take both the drugs and continue Niftran for 10 days. Take plenty of fluids to keep urinary trat flushed to prevent recurrence. Take care. Good Luck. Dr.Akhilesh Dubey M.D.