Dear efreedland, Periogen is not reported to be associated with any such sideeffects like Migrane. Occurence of Migrane during usage of periogen was merely a Co-incidence. Migrane can be eggravated because of certain environmental factors like weather, Temperature, pollution, sound, light etc. Migrane headaches are usually episodic in nature and you may experience similar pain sometime in future , it is advisable to recognize the aggravating factor and avoid it as much as possible. Incase of severe migrane headache you can use Sumatriptan 25 mg, if usual painkillers are not effective. Take care.