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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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Knee Replacement Surgery,taking Coumadin, Lyrica, Celebrex, Liver Enzymes Increased In Blood Report

I recently had knee replacement surgery (7 weeks)... At that time I was on numerous medications from Coumadin, Lyrica , Celebrex , to the daily Ecotrin which I am still taking. A blood work up last week found slightly elevated liver enzymes . Could this elevation be the result of all these afore mentioned prescription drugs?
Thu, 24 Oct 2013
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Internal Medicine Specialist,  's  Response
Hi there,

Thanks for your query.

Yes. Majority of the drugs are toxic to either liver/kidneys or both.

Some of your medicines are toxic to the liver and hence, slightly elevated liver enzymes. You have not mentioned the values of the enzymes. However, dose of the causative drug has to reduced or even stopped, once the liver enzymes exceed a certain level.

Consult your treating doctor, who knows which drugs are responsible for elevated liver enzymes and when to reduce the doses/stop the drug.

Dr. Rakesh Karanwal
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Knee Replacement Surgery,taking Coumadin, Lyrica, Celebrex, Liver Enzymes Increased In Blood Report

Hi there, Thanks for your query. Yes. Majority of the drugs are toxic to either liver/kidneys or both. Some of your medicines are toxic to the liver and hence, slightly elevated liver enzymes. You have not mentioned the values of the enzymes. However, dose of the causative drug has to reduced or even stopped, once the liver enzymes exceed a certain level. Consult your treating doctor, who knows which drugs are responsible for elevated liver enzymes and when to reduce the doses/stop the drug. Dr. Rakesh Karanwal