Hello, Thanks for choosing health care magic for posting your query. I have gone through your question in detail and I can understand what you are going through. It seems that along with the aspergers disorder your grandson is also having gender identity disorder. Both these illnesses are not treatable with drugs. They need intensive psychotherapy and the treatment duration is also very long. You need to have patience and show your grandson to a psychologist who is trained in psychotherapies. Hope I am able to answer your concerns. If you have any further query, I would be glad to help you. In future if you wish to contact me directly, you can use the below mentioned link: bit.ly/dr-srikanth-reddy Wish you good health, Kind regards Dr. Srikanth Reddy M.D.