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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is Fragmin Effective In The Treatment Of Factor V Leiden Thrombophilia?

Hi I have factor 5 lieden and for many years I have been prescribed a clexane injection before I fly which was advised by the heamotologist after Getting a blood clot in my lung . Today i tryed to order my injection from the doctor as usual only to be told the health authority will not allow them to prescribe it any more! So they have given me Fragmin instead which is half the strength dose which the specialist advised and involves a lot more injections. I was also told that it was not covered by the NHS and had to pay £34.00 privately. In the pharmacy I could see clexane on the shelf so it s obviously available to some . I m confused , can you put my mind to rest that Fragmin is as effective ?. Thankyou Sally
Mon, 6 Aug 2018
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Internal Medicine Specialist 's  Response
Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.

Yes, it is useful in factor five Leiden mutations dosage may vary boy usual dosage is 150-200 Iu/mg once a day.

As a prophylaxis dosage may be 100-150 Iu/kg life long treatment may required.

Also check for injection site hematoma, thrombocytopenia or major hemorrhage etc.

If symptoms not improved please consult your doctor, he will examine and treat you accordingly.

Take care.
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Is Fragmin Effective In The Treatment Of Factor V Leiden Thrombophilia?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Yes, it is useful in factor five Leiden mutations dosage may vary boy usual dosage is 150-200 Iu/mg once a day. As a prophylaxis dosage may be 100-150 Iu/kg life long treatment may required. Also check for injection site hematoma, thrombocytopenia or major hemorrhage etc. If symptoms not improved please consult your doctor, he will examine and treat you accordingly. Take care.