Hi & Welcome. Yes, it may be given under close monitoring. Clostridium difficile induced diarrhea has been associated with the use of nearly all antibacterial agents, including Clindamycin and may range in severity from mild diarrhea to fatal colitis. Clindamycin can be given safely to elderly person under careful monitoring for change in bowel frequency. He should consult his treating PCP if he gets three or more watery stools a day and symptoms lasting more than two days or if he developes fever, severe abdominal pain or cramping, or blood in the stool. There s no harmful interaction between the antiobitoic Clindamycin and blood thinner Eloquis hence can be given as prescribed. Hope these answer your queries. Best regards.