** Thanks for contacting with your health concern. 1. ADR [adverse drug reaction] of clindamycin itself is DIARRHEA along with other exhaustive lists, and since it is a prescription drug so even if seeking for any other safer alternative consult your attending dentist or a Medicine specialist. PS. This drug has a black box warning issued by FDA which alerts doctor/patient about the drug effects that may be dangerous: as it causes clostridium difficile associated diarrhea [which can cause mild diarrhea or severe inflammation of your colon] 2. The American Heart Association guidelines for antibiotic prophylaxis has given two alternatives to clindamycin: azithromycin and clarithromycin [both in 500 mg] single dose but you shouldn t take them without first consulting with your doctor.