Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. He requires thorough counselling and cognitive behaviour therapy. All the family members need to be very supportive and caring towards him. Some tips that i would like to suggest him to follow 1. Connect with others: Loneliness and isolation set the stage for anxiety. Decrease your vulnerability by reaching out to others. Make it a point to see friends, join a self-help or support group, or share your worries and concerns with a trusted loved one. 2. Practice relaxation techniques: When practiced regularly, relaxation techniques such as mindfulness meditation, progressive muscle relaxation, and deep breathing can reduce anxiety symptoms and increase feelings of relaxation and emotional well-being. 3. Get enough sleep: A lack of sleep can exacerbate anxious thoughts and feelings, so try to get seven to nine hours of quality sleep a night. If you struggle with sleep, adopting smart sleep habits can make a big difference. 4. Be smart about caffeine and alcohol: If you struggle with anxiety, you may want to consider reducing your caffeine intake or cutting it out completely. Same with alcohol, which can make anxiety worse. 5. Train your brain to stay calm: Worrying is a mental habit you can learn how to break. Strategies such as creating a worry period, challenging anxious thoughts, and learning to accept uncertainty can significantly reduce anxiety and fear. If his anxiety is so severe enough that it is interfering in his day to day life then he needs to consult a psychiatrist and be on regular medications. Since MRI says nothing wrong, there may not be any organic cause that needs to be treated. Hope I have answered your query. Let me know if I can assist you further.