Hello, I am Having wound care, for a horrid ulceration on my right leg, and taking 2 Advil & 2 tylenol,combo together--- 2x a day. There is nerve pain so much that it is excruciating- as bad as the ulceration treatment. Our if my mind with pain. Infectious disease physician is involved as I had taken 2 rounds of antibiotics. Also to complicate matters, there s been vein prolapse lower legs, that I m having fixed in week. One leg at a time, to help with looking blood, etc. It s like a soap opera already.prior to this I led a normal life. But I am fearful and feel quite anxious now, in anticipation of going to Dr visits and wound clinic 2x a week. The dr. Advised I take zoloft. I m aporehensive! I only have Tylenol and Advil for pain! I agree, I think I need something to get me through this wicked pain---but zoloft and nsaids don t mix! What are your thoughts? I have not started zoloft yet, I am very afraid.