Hello It is common to have slight alteration of the menstrual cycles while you are on Depot, as well as after stopping it, as it is a hormonal preparation. However, the only way to be sure is to have an Ultrasound examination and consult with a gynecologist. Only that will definitely tell you whether you are pregnant, and also, if not, then what is the cause for your irregular bleeding pattern. You have had equivocal pregnancy tests, so do not repeat any more. The signs of breast soreness may occur during early pregnancy, but the rest of the problems you describe do not fit in . So please go for an examination and Ultrasound as it will greatly clarify matters. Hope this helped you.