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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Cerebellar Atrophy Cause Cancer?

Hi, I am a 52 year old male who was diagnosed with cebellar ataxia within the last 3 years. I have had similar problems dating back to 2007 . At that time saw a neurologist and after 3 years of tests and pokes the only conclusion was it might be the stat of MS or Cancer. Well, Cancer did come a calling two years later in the form of colon cancer. I did not go back to a neurologist until 3 years ago complaining of balance and speech issues along with eyes twitching. She did multiple test including MRI of the brain that showed my cerebellum only 1/3 the size it should be. My two questions are: my neurologist feels my cerebellum caused my cancer and can cause cancer again. Is this true? And how? My oncologist agrees with my neurologist. Also what is the life expectancy of someone my age with this disease? We do not know why my cerebellum is shrinking because I do not drink or have never had a stroke and no family history of this.
Fri, 21 Sep 2018
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Neurologist 's  Response
Hello,

I am afraid I don't agree with what you have been told. Cerebellar atrophy doesn't cause cancer. Cerebellar atrophy can't even be called a condition, it is simply a descriptive Latin term meaning shrinking of the little brain, doesn't indicate the origin, may be in the setting of different causes with different mechanisms.

I think what the doctors must have meant is the other way round, that it is the colon cancer which has caused the cerebellar atrophy. It is known for cancer to cause Paraneoplastic syndromes in other organs, meaning affecting other organs in distance without the cancer having spread there. Cerebellar atrophy or degeneration is a well know neurological paraneoplastic syndrome. It is as a result of the body's immune system reacting to the cancer cells creating abnormal antibodies and an abnormal immune response which affects the cerebellum, even in the absence of as direct spread of the cancer there.

It may start well before the tumor is diagnosed, even years, when there are malignant cells triggering the immune response but the tumor is not yet big enough to be detected. So it is the cancer which has caused the cerebellar atrophy. Of course you should discuss with your doctors again as I don't have your reports.

Hope I have answered your query.
Let me know if I can assist you further.

Regards,
Dr. Olsi Taka,
Neurologist
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Does Cerebellar Atrophy Cause Cancer?

Hello, I am afraid I don t agree with what you have been told. Cerebellar atrophy doesn t cause cancer. Cerebellar atrophy can t even be called a condition, it is simply a descriptive Latin term meaning shrinking of the little brain, doesn t indicate the origin, may be in the setting of different causes with different mechanisms. I think what the doctors must have meant is the other way round, that it is the colon cancer which has caused the cerebellar atrophy. It is known for cancer to cause Paraneoplastic syndromes in other organs, meaning affecting other organs in distance without the cancer having spread there. Cerebellar atrophy or degeneration is a well know neurological paraneoplastic syndrome. It is as a result of the body s immune system reacting to the cancer cells creating abnormal antibodies and an abnormal immune response which affects the cerebellum, even in the absence of as direct spread of the cancer there. It may start well before the tumor is diagnosed, even years, when there are malignant cells triggering the immune response but the tumor is not yet big enough to be detected. So it is the cancer which has caused the cerebellar atrophy. Of course you should discuss with your doctors again as I don t have your reports. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Olsi Taka, Neurologist