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Does Mysoline Interact With Zonegran?
I am taking Zenogran and Mysoline together both were persribed by the same doctor, apparently she didn t look at her records. I have been taking the two for at least now together for 5 years if not more. What side affects are going to be worse because of the interactions with them both?
Tue, 10 Sep 2019
Hi,
No. There are no significant interactions between the two and can be safely administered together. Concomitant administration of Zonegran and alcohol or other CNS depressant drugs has not been evaluated in clinical studies.
Because of the potential of Zonisamide to cause CNS depression, as well as other cognitive and/or neuropsychiatric adverse events, Zonisamide should be used with caution if used in combination with alcohol or other CNS depressants.
Other Carbonic Anhydrase Inhibitors
Concomitant use of ZONEGRAN, a carbonic anhydrase inhibitor, with any other carbonic anhydrase inhibitor (e.g., topiramate, acetazolamide or dichlorphenamide), may increase the severity of metabolic acidosis and may also increase the risk of kidney stone formation. Therefore, if Zonegran is given concomitantly with another carbonic anhydrase inhibitor, the patient should be monitored for the appearance or worsening of metabolic acidosis.
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Ajeet Singh, General & Family Physician
No. There are no significant interactions between the two and can be safely administered together. Concomitant administration of Zonegran and alcohol or other CNS depressant drugs has not been evaluated in clinical studies.
Because of the potential of Zonisamide to cause CNS depression, as well as other cognitive and/or neuropsychiatric adverse events, Zonisamide should be used with caution if used in combination with alcohol or other CNS depressants.
Other Carbonic Anhydrase Inhibitors
Concomitant use of ZONEGRAN, a carbonic anhydrase inhibitor, with any other carbonic anhydrase inhibitor (e.g., topiramate, acetazolamide or dichlorphenamide), may increase the severity of metabolic acidosis and may also increase the risk of kidney stone formation. Therefore, if Zonegran is given concomitantly with another carbonic anhydrase inhibitor, the patient should be monitored for the appearance or worsening of metabolic acidosis.
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Ajeet Singh, General & Family Physician
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