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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Amiodarone Interact With Digoxin?

My cardiologist prescribed digoxin to get my heart rate down from 140 bpm during an a fib episode along with Eliquis. Now he has prescribed amiodarone for the a fib. my pharmacist said amiodarone was contraindicated with digoxin. I very confused and about to leave town for 5 days. I have a call into his office but have not heard back yet. what to do?
Thu, 23 Aug 2018
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General & Family Physician,  's  Response
Hi,

Digoxin is a drug which is used to treat congestive heart failure. Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of irregular heartbeats. Digoxin and amiodarone are medications that are commonly used in patients with heart failure and arrhythmias. There is a potential for serious interaction and hence regular monitoring by your doctor necessary or alternate medication may need to be prescribed. The co-administration of amiodarone and digoxin can increase the serum concentrations of digoxin and the risk for digoxin toxicity as these drugs compete for the same pathway for excretion through the kidneys. Kindly consult your doctor regarding this matter and follow the advise.

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Does Amiodarone Interact With Digoxin?

Hi, Digoxin is a drug which is used to treat congestive heart failure. Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of irregular heartbeats. Digoxin and amiodarone are medications that are commonly used in patients with heart failure and arrhythmias. There is a potential for serious interaction and hence regular monitoring by your doctor necessary or alternate medication may need to be prescribed. The co-administration of amiodarone and digoxin can increase the serum concentrations of digoxin and the risk for digoxin toxicity as these drugs compete for the same pathway for excretion through the kidneys. Kindly consult your doctor regarding this matter and follow the advise. Hope I have answered your query. Let me know if I can assist you further.