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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Do Lipitor And Plavix Elevate The Uric Acid Level?

peripheral vascular disease surgery with bypass and angioplasty has failed to relieve claudication symptoms so i am wondering about the side effects of both lipitor and plavix with regard to symptoms /claudication and neuropathy; also do either drug promote an elevation of uric acid? I am a retired cardiologist and friend has the above problem
Mon, 14 Mar 2016
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Internal Medicine Specialist 's  Response
Thanks respected colleague for asking at Healthcare magic.
I read your question and I understand your concern.
Lipitor (Atorvastatin) decrease uric acid level while clopidogrel (Plavix) increase uric acid level how ever atorvastatin significantly decrease uric acid.
Hence the net effect is normal or decrease uric acid level.
Joints pains, myopathies, tendon rupture, neuropathy... however it's incidence is very less than two percent.
I would like to suggest that it is not due to these drugs as they are foremost important after surgery.
It's the failure of surgical procedure or the venous graft quality that has led to failure of surgery.
Repeat His Doppler ultrasongraphy of arterial system of lower limbs and then consult the operating surgeon.
Hope it helps best.
Take your best care.
Don't forget to rate this answer.
I will be glad to have your follow-up.
Regards
Dr Ejaz
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Do Lipitor And Plavix Elevate The Uric Acid Level?

Thanks respected colleague for asking at Healthcare magic. I read your question and I understand your concern. Lipitor (Atorvastatin) decrease uric acid level while clopidogrel (Plavix) increase uric acid level how ever atorvastatin significantly decrease uric acid. Hence the net effect is normal or decrease uric acid level. Joints pains, myopathies, tendon rupture, neuropathy... however it s incidence is very less than two percent. I would like to suggest that it is not due to these drugs as they are foremost important after surgery. It s the failure of surgical procedure or the venous graft quality that has led to failure of surgery. Repeat His Doppler ultrasongraphy of arterial system of lower limbs and then consult the operating surgeon. Hope it helps best. Take your best care. Don t forget to rate this answer. I will be glad to have your follow-up. Regards Dr Ejaz