Hi there, Thank you for your question. GI discomfort is something that is very common in people who use metformin or combinations that contain metformin. The way I usually deal with this kind of problem is that I usually would not use a combination. What I would do is that I would use a sustained release formulation of metformin such as glucophage SR. This will lead to significantly lesser GI upset. Along with that I would use something like vildagliptin or sitagliptin plus another drug like glimipiride or any other type of antidiabetic medication belonging to the sulfonylurea group. So the bottom line is that you need to have your medications changed a little bit to decrease your stomach discomfort. Another thing that you may want to try is that you may want to try taking something like domperidone (motilium) one tablet three times daily before meals. This tablet increases the motility of the stomach and may help in reducing your symptoms. Kindest Regards