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Could HCV Therapy Cause Addison's Disease?
Hi Doctor, I have active HCV-2b contracted during my 20 year urban EMS career (no other high risk factors or behaviors). I was dx. 1/21/2000 & have been unsuccessfully tx x3 with different variations of Interferon with Ribavirin. My last tx. was stopped due to non-response in 2004. As of 12/2011 I have been dx with Addison's Disease. I only have disability coverage for HCV issues. I have resd that HCV therapy can cause Addison's. Is this at all plausible? Thank you, Mary
Mon, 1 Oct 2018
Hi,
The infection of hepatitis C and the respective therapy is not a common cause of adrenal insufficiency or Addison's disease.
It is true that there are some case reports where exacerbation of hepatitis C induced subclinical hypoadrenalism by interferon alpha 2 beta therapy.
Anyway, this is not a plausible cause because you have been diagnosed with Addison's disease 7 years after you stopped the HCV therapy.
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Elona Xhardo,
Endocrinologist
The infection of hepatitis C and the respective therapy is not a common cause of adrenal insufficiency or Addison's disease.
It is true that there are some case reports where exacerbation of hepatitis C induced subclinical hypoadrenalism by interferon alpha 2 beta therapy.
Anyway, this is not a plausible cause because you have been diagnosed with Addison's disease 7 years after you stopped the HCV therapy.
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Elona Xhardo,
Endocrinologist
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