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Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Pristiq be taken while on Trazodone?

I am currently taking 100mg of Pristiq in the morning. I have problems sleeping and my primary care doctor has prescribed 50 mg of Trazodone to take at night. I will see the physchiatris on the 30 th of this month. Should I wait til then before taking the Trazodone?
Fri, 23 Feb 2018
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General & Family Physician 's  Response
Hi & Welcome.
It's not safe to take Pristiq while on Trazodone.

If Pristiq is taken while on Trazodone this can increase the risk of a rare but serious condition called the serotonin syndrome which is characterized by confusion, hallucination, convulsion (fits), high BP and increased heart rate, fever, excessive sweating, blurred vision, muscle stiffness, tremor, stomach cramps, nausea, vomiting, and diarrhea.

In its severe form it may result in coma and even death.

You need to consult your doctor for an alternate effective but a safer medication for your sleep related issues.

Hope this answers your query.
Best regards.
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