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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Paroxetine, Wellbutrin And Risperidone Be Taken Together?

I recently discovered I take three medications metabolized by the Sam e liver enzyme, paroxetine 20mg, wellbutrin300mg, risperidone .75mg for 3 years. I can t get a consistent answer to this question from a pharmacist. Was this into a good idea for my DR to prescribe me these meds together? I ve had a couple of pharmacist tell me not to worry that it is rare for drugs to alter th metabolism of other drugs. I would appreciate a Dr s opinion on this. Thank you
Wed, 29 Aug 2018
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Endocrinologist,  's  Response
Hi,

It is true what you said about your drugs. There are possible interactions between your drugs and these can be dangerous for you. Combining Wellbutrin or Bupropion together with Paroxetine and Risperidone may increase the risk of seizures, which may occur rarely with either medication.

In addition, Wellbutrin can increase the blood levels of Paroxetine and Risperidone which may increase other side effects. Even the combination of Paroxetine and Risperidone can be dangerous. This combination may increase the effects of risperidone.

This can cause development of extrapyramidal symptoms resulting in tremor, shuffling of your feet, muscle spasms or rigidity, and involuntary movements. It is very important to tell your doctor if you have any of these symptoms.

You may need a dose adjustment for these two medications. My advice is to discuss with your treating doctor about your drugs and the possible side effects, interactions between them and if it is necessary to change the therapy.

Hope I have answered your query. Let me know if I can assist you further.
Regards,     
Dr. Elona Xhardo
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Can Paroxetine, Wellbutrin And Risperidone Be Taken Together?

Hi, It is true what you said about your drugs. There are possible interactions between your drugs and these can be dangerous for you. Combining Wellbutrin or Bupropion together with Paroxetine and Risperidone may increase the risk of seizures, which may occur rarely with either medication. In addition, Wellbutrin can increase the blood levels of Paroxetine and Risperidone which may increase other side effects. Even the combination of Paroxetine and Risperidone can be dangerous. This combination may increase the effects of risperidone. This can cause development of extrapyramidal symptoms resulting in tremor, shuffling of your feet, muscle spasms or rigidity, and involuntary movements. It is very important to tell your doctor if you have any of these symptoms. You may need a dose adjustment for these two medications. My advice is to discuss with your treating doctor about your drugs and the possible side effects, interactions between them and if it is necessary to change the therapy. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Elona Xhardo