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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Fluconazole Be Taken After Taking A Dose Of Omeprazole?

I have received a prescription today for fluconazole. I have been taking omeprazole in the morning before eating. Is there any danger in taking fluconazole this evening (9/23)? Is it wise to skip the omeprazole in the morning? Or until the third day when the second fluconazole is to be taken?
Fri, 14 Oct 2016
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General & Family Physician,  's  Response
Hi & Welcome.
Avoid taking Fluconazole after taking a dose of Omeprazole.

Since the antifungal medication Fluconazole can inhibit the metabolism (slow down the breakdown) of Omeprazole by the liver enzymes (cytochromes) causing increasing the blood levels of Omeprazole.

This may increase side effects such as diarrhea, abdominal pain, vomiting, and flatulence on short term treatment.

During long-term treatment, you may also have an increased risk of developing osteoporosis (thinning of the bones & fractures), deficiency of vitamin B12, increased risk of certain intestinal infections & a condition called hypomagnesemia (low blood magnesium), which in severe cases can lead to muscle spasm, irregular heart rhythm, and seizures.

Consult your treating doctor to prescribe alternatives (like Ranitidine to treat your acidity related stomach issues) that do not interact, or you may need a dose adjustment or more frequent monitoring.

Hope the suggestion given above would help you.
A feedback is appreciated.
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Can Fluconazole Be Taken After Taking A Dose Of Omeprazole?

Hi & Welcome. Avoid taking Fluconazole after taking a dose of Omeprazole. Since the antifungal medication Fluconazole can inhibit the metabolism (slow down the breakdown) of Omeprazole by the liver enzymes (cytochromes) causing increasing the blood levels of Omeprazole. This may increase side effects such as diarrhea, abdominal pain, vomiting, and flatulence on short term treatment. During long-term treatment, you may also have an increased risk of developing osteoporosis (thinning of the bones & fractures), deficiency of vitamin B12, increased risk of certain intestinal infections & a condition called hypomagnesemia (low blood magnesium), which in severe cases can lead to muscle spasm, irregular heart rhythm, and seizures. Consult your treating doctor to prescribe alternatives (like Ranitidine to treat your acidity related stomach issues) that do not interact, or you may need a dose adjustment or more frequent monitoring. Hope the suggestion given above would help you. A feedback is appreciated.