I have a friend who had depression, no motivation, wanted to sleep all the time, did not want to face each day, etc. and started taking Lamotrigine based on the psychiatrist recomendation and had great results. I understand there are certain other drugs that can cause serious intereactions if taken with Lamotrigine. I take Amlodipine Bysylate- 5mg, Losartan Potassium-50mg,Allpurinol - 300mg, Centrum Sliver, Wellbutrin 150mg for depression, Vesicare 5mg & Alfuzosin 10mg for my urinary discharge problem. Ii am also taking Walgreens Mucus Relief D for my sinus and post nasal drip. Will any of these cause a problem with Lamotrigine ? George