Hello there, Gupisone is a good medication for any inflammatory process. It is an steroid so it should be taken for certain conditions with specific dose and length of treatment. Whille this medication is effective in areas with swelling, it also lowers the patients immune system in the process such that opportunistic bacteria, virus or fungi would defeat our body s defenses. In this case, oral thrush most commonly due to a weak fungus causes this painful condition in the oral cavity. It is a common side effect in patients taking this kind of medication. There are over the counter medicines for this. You may give us your feedback if symptoms persist. Thank you. Dr. Eric