Close folllow up needed to monitor titre.
Hi. Thanks for posting your concern at XXXXXXX
There are 11 clinical criteria for a lupus dx. You must have at least 4 of the 11 to recieve a dx. These 4 criteria can be positive simultaneously or serially during a given period of observation.
1. malar rash over cheeks (butterfly rash
2. discoid rash, red raised patches
- reaction to sunlight, resulting in skin rash
4. oral and nose ulcers
6. serositis - inflamation (inflammation) of the lining of the lung or heart
7. renal disorder - excessive protein in urine
and/or cellular casts
8. neurologic disorder - seizures, or psychosis
9. anemia or low white blood count or lymphopenia or low platelet count
10. positive ANA
11. positive anti-dsDNA or anti-Sm, or antiphospholipid antibody or false pos. syphilis test
Anti-dsDNA are highly diagnostic of systemic lupus erythematosus
(SLE) and are implicated in lupus nephritis
People who have positive ANA or Anti-ds DNA but cannot fulfill the clinical criteria for SLE need to be followed closely because they are at risk to develop SLE in future.
Anti-dsDNA antibodies can be present in normal individuals, however these antibodies are usually low avidity IgM isotype. In contrast, pathogenic anti-dsDNA antibodies found in SLE are usually of IgG isotype and show high avidity for dsDNA.
Titers of anti-dsDNA antibodies often fluctuate with disease activity, especially lupus nephritis, and are therefore useful in many patients for following the course of SLE. If a patient has a rising titer, or very high titer, but clinically is quiescent, it is considered a warning sign that the patient needs to be followed more closely.
I would recommend a repeat test for both ANA with titresas well as anti-dsDNA with titres. Very high titres or rising titres do indicate need for a close watch.
I would advice that you visit a dermatologist
as well as a rheumatologist
and discuss regarding your test results keeping all these points in mind. Your treating doctor might ask you to repeat the test in some time to monitor the titre.