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Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest treatment for fatigue, recurrent infections and splenomegaly

Answered by
Dr. Deepak Sundriyal


Practicing since :2005

Answered : 1546 Questions

Posted on Thu, 14 Jul 2016 in Cancer
Question: 1.     An adult patient presents with fatigue, frequent infections, and splenomegaly. You suspect a white blood cell malignancy.
a.     Which malignancies could present with these symptoms?
b.     What test(s) would you need to carry out to determine which malignancy type the patient has? Explain what test results you would expect for each possible malignancy type.
Answered by Dr. Deepak Sundriyal 17 minutes later
Brief Answer:
Hello dear. This is the usual case with NHL and acute leukemias

Detailed Answer:
Hello dear. This is the typical presentation with non hodgkin lymphoma like SLL/CLL(small/chronic lymphocytic leukemia), hairy cell leukemia, and splenic lymphoma. Sometimes acute lymphocytic leukemia may have this picture.

Folowing tests are required:
Complete blood counts, peripheral smear, Liver Kidney function tests, Tumor lysis panel, B2 microglobulin, LDH, marrow aspiration and biopsy, immunohistochemical markers, A flowcytometry analysis of the marrow or peripheral blood and cytogenetic analysis if we are suspecting acute leukemia.
A PETCT may be required if non hodgkin lymphoma is the malignancy.
Thanks and regards
Above answer was peer-reviewed by : Dr. Prasad

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