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Is Ultitar CS Lotion Safe To Use For Psoriasis?
Question: Dear Sir,
I am XXXXXXX 10 days back i had asked your certain questions by providing required information related to psoriasis problem treatment of biological and folitrax. I got good knowledge after your valuable replies.
Now i am not using folitrax tablet with fear of side affects,
Recently i am using some external applications to manage psoriasis on various areas of my skins expect face. I am applying ULTITAR CS LOTION, ELOCON OINTMENT etc., which are having some steroids.
Is it safe to use these Lotions and creams for long time to manage Prosiness patches? With these Lotions and creams i am getting very good relief of Psoriasis patches. Will be there any side affects of these creams and lotions.
Secondly if i am managing with external creams to clear patches without taking any internal medicine; what will be the progress / status of internal psoriasis developments ? please brief me,
with regards
XXXXXXX
I am XXXXXXX 10 days back i had asked your certain questions by providing required information related to psoriasis problem treatment of biological and folitrax. I got good knowledge after your valuable replies.
Now i am not using folitrax tablet with fear of side affects,
Recently i am using some external applications to manage psoriasis on various areas of my skins expect face. I am applying ULTITAR CS LOTION, ELOCON OINTMENT etc., which are having some steroids.
Is it safe to use these Lotions and creams for long time to manage Prosiness patches? With these Lotions and creams i am getting very good relief of Psoriasis patches. Will be there any side affects of these creams and lotions.
Secondly if i am managing with external creams to clear patches without taking any internal medicine; what will be the progress / status of internal psoriasis developments ? please brief me,
with regards
XXXXXXX
Brief Answer:
Topical treatment may be sufficient for limited skin involvement
Detailed Answer:
Hi. Thank you for writing to me.
If you have limited skin involvement then topical applications is the preferred mode of treatment. However, in more widespread involvement topical treatment is commonly used in combination with oral treatment.
Topical treatment options consist of steroid based cream/ ointments, coal tar and salicylic acid ointment, vitamin D analogues (calcipotril, calcipotriene), psoralens etc.
Topical steroids based creams/ lotions are good options for limited skin involvement with psoriasis patches, however, they should be used judiciously i.e a few weeks of potent topical steroids and then either tapered to a lower potency steroid before finally discontinuing them Or they should be substituted with safer topical preparations like Vitamin D analogues once significant disease control has been achieved. Topical steroids cannot be used forever because of risk of side effects like skin atrophy and hypopigmentation. Therefore topical steroids should be used under supervision of a dermatologist and only for the duration precribed.
In psoriasis there is immune dysregulation which is expressed as altered levels of dertain T cells and cytokines secreted by these immune cells. However, even though psoriasis is not just a skin disease but treatment is tailored to the severity of skin invovement i.e only topicals may suffice for limited skin disease.
Regards
Topical treatment may be sufficient for limited skin involvement
Detailed Answer:
Hi. Thank you for writing to me.
If you have limited skin involvement then topical applications is the preferred mode of treatment. However, in more widespread involvement topical treatment is commonly used in combination with oral treatment.
Topical treatment options consist of steroid based cream/ ointments, coal tar and salicylic acid ointment, vitamin D analogues (calcipotril, calcipotriene), psoralens etc.
Topical steroids based creams/ lotions are good options for limited skin involvement with psoriasis patches, however, they should be used judiciously i.e a few weeks of potent topical steroids and then either tapered to a lower potency steroid before finally discontinuing them Or they should be substituted with safer topical preparations like Vitamin D analogues once significant disease control has been achieved. Topical steroids cannot be used forever because of risk of side effects like skin atrophy and hypopigmentation. Therefore topical steroids should be used under supervision of a dermatologist and only for the duration precribed.
In psoriasis there is immune dysregulation which is expressed as altered levels of dertain T cells and cytokines secreted by these immune cells. However, even though psoriasis is not just a skin disease but treatment is tailored to the severity of skin invovement i.e only topicals may suffice for limited skin disease.
Regards
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Dear Sir,
Thank you for your reply.
In my earlier questions, I had asked about SCAPHO (secukinumab) biological injection treatment. It contains active substance secukinumab and it is. a monoclonal antibody. It is by NOVARTIS.
They are quoting that this injection is unlike general immunosuppressants that suppress the entire immune system, it is only works selectivly by neutralising the activity of a protein called IL-17A, which is reason in increased levels of Psoriasis.
Can you give me some feedback about accurate of this information ?
It is not suppressing entire immune system and only working on IL-17A, what will be the chances of side affects ?
Sir, we want to get updated in all respects before go to any biological injection, as we already used folitrax for long time.
I am waiting for your reply.
Thank you for your reply.
In my earlier questions, I had asked about SCAPHO (secukinumab) biological injection treatment. It contains active substance secukinumab and it is. a monoclonal antibody. It is by NOVARTIS.
They are quoting that this injection is unlike general immunosuppressants that suppress the entire immune system, it is only works selectivly by neutralising the activity of a protein called IL-17A, which is reason in increased levels of Psoriasis.
Can you give me some feedback about accurate of this information ?
It is not suppressing entire immune system and only working on IL-17A, what will be the chances of side affects ?
Sir, we want to get updated in all respects before go to any biological injection, as we already used folitrax for long time.
I am waiting for your reply.
Brief Answer:
Secukinumab is a selective immunosuppresant
Detailed Answer:
Hi.
Yes, secukinumab selectively alters the Th17 immune system by blocking IL-17, therefore it is not a general immunosuppresant like folitrax.
It increases risk of infections with candida/ yeast which can be treated with antifungals. Nevertheless screening for other infections like latent or active tuberculosis is recommended prior to starting secukinumab as well as prior hepatitis and HIV should also be ruled out.
Regards
Secukinumab is a selective immunosuppresant
Detailed Answer:
Hi.
Yes, secukinumab selectively alters the Th17 immune system by blocking IL-17, therefore it is not a general immunosuppresant like folitrax.
It increases risk of infections with candida/ yeast which can be treated with antifungals. Nevertheless screening for other infections like latent or active tuberculosis is recommended prior to starting secukinumab as well as prior hepatitis and HIV should also be ruled out.
Regards
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Thank you for your reply. You have provided us very valuable information.
So you are sure that it is selectively altering the Th17 immune system by blocking IL-17. In this case SCAPHO is better than folitrax, which is immunosuppressant.
Sir, We want to go ahead completely based on your input only.
Do you have any feedback / input about people experience, who had taken SCAPHO injections for psoriasis treatment ?
Will be any life threatening side affects, if we are taking this injection after all preliminary test like TB, Hepatitis and HIV etc.,
You are saying there is chance of Candida/Yeast infection due to SCAPHO, will be any serious risk with these additional infections ?
Please sir, clear me these points to reach to final conclusion
Brief Answer:
Biologicals are a good choice for psoriasis
Detailed Answer:
Hi.
Personally I have not used secukinumab till now. I have used other biologicals like adalimumab and infliximab. Whenever indicated, biologicals are certainly better than tradaitional immunosuppressives in terms of risk of side effect profile and durable response. They are safe for use and recommended. Candidal infections can be easily managed with antifungals, if and when they occur.
Regards
Biologicals are a good choice for psoriasis
Detailed Answer:
Hi.
Personally I have not used secukinumab till now. I have used other biologicals like adalimumab and infliximab. Whenever indicated, biologicals are certainly better than tradaitional immunosuppressives in terms of risk of side effect profile and durable response. They are safe for use and recommended. Candidal infections can be easily managed with antifungals, if and when they occur.
Regards
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Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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