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Can MTHFR Deficiency Cause Depression?

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Posted on Thu, 12 Mar 2015
Question: can mthfr cause depression
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Answered by Dr. Indu Kumar (28 minutes later)
Brief Answer:
Yes,MTHFR deficiency is associated with depression.

Detailed Answer:
Hello

Methylenetetrahydrofolate reductase(MTHFR )gene gives instructions for making an enzyme known as methylenetetrahydrofolate reductase.This enzyme plays a role in processing aminoacids like folate vitamin.

Many studies indicate that folate deficiency is associated with depression.Folate deficiency is associated with low levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) which causes depression.
So,MTHFR deficiency is associated with depression.

Hope I have answered your question.
Further queries are most welcome.

Take Care
Dr.Indu XXXXXXX
Note: For further guidance on mental health, Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Indu Kumar

Radiologist

Practicing since :2004

Answered : 6729 Questions

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Can MTHFR Deficiency Cause Depression?

Brief Answer: Yes,MTHFR deficiency is associated with depression. Detailed Answer: Hello Methylenetetrahydrofolate reductase(MTHFR )gene gives instructions for making an enzyme known as methylenetetrahydrofolate reductase.This enzyme plays a role in processing aminoacids like folate vitamin. Many studies indicate that folate deficiency is associated with depression.Folate deficiency is associated with low levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) which causes depression. So,MTHFR deficiency is associated with depression. Hope I have answered your question. Further queries are most welcome. Take Care Dr.Indu XXXXXXX