Hi, thanks for writing to HCM. An aggressive method of treament or approach is necessary for Acute osteomyelitis so as to prevent it from not becoming CHRONIC OSTEOMYELITIS. The mainstay of treatment is by INTRAVENOUS ANTIBIOTICS. Antibiotic treatment is usually continued for 6 weeks for osteomyelitis. The choice of the antibiotic depends on the sensitivity of the organism to that particular antibiotic. MRSA (Methicillin resistant staph aureus) is the most common resistant bacteria encountered in orthopedic practice now a days. A 6-week course of vancomycin (1 g IV every 12 hours) is the current standard treatment for MRSA. However, this drug has relatively poor bone penetration, and it requires close monitoring because it can cause nephrotoxicity and ototoxicity. CLINDAMYCIN has got excellent bone penetration potential and is also active against staph.aureus. So this is preferred but it rarely causes a potentially lethal complication - PSEUDO MEMBRANOUS COLITIS. Newer antibiotics like LINEZOLID which are active against MRSA are currently available and can be taken ORALLY. Erythrocyte sedimentation rates (ESRs) and C-reactive protein (CRP) levels should be serially checked weekly or semiweekly to monitor the success of treatment Hope this information is helpful. Good day