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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Increased Levels Of Sgot And Agpt During Pregnancy?

Hello Doc, my spouse is in 28 weeks of pregnancy with some associated problems. Swelling in both legs, reduce after elevation of foot and rest. last 2 weeks back SGOT is 25 and SGPT is 18 But we checked again on 2nd JUNE, its highly elevated. SGOT - 2360 and 1580, SGPT - 1560 and 1404 from 2 different labs, Alkaline phosphate is also elevated (527) and bilirubin is in normal range, the remaining all parameters in normal value. She is in medication of T.Duphastan, T.Shelcal, T. Iron supplement and T. Thyroxin. She have a Hypothyroidism since last 1 year. I am a Registered Nurse in india. i want to what is happening to her and what is the possibilities? today i took the sample fr Hepatitis A, B, C, E and Urine routine?
Thu, 28 Jan 2016
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OBGYN 's  Response
Hello, and I hope I can help you today.

Elevated liver enzymes and swelling unfortunately can be symptoms of two potentially very dangerous pregnancy complications. The first and most common is severe preeclampsia or HELLP syndrome which is a combination of hypertension, swelling and protein in the urine. It normally develops at term but if it does prematurely it can cause seizures in the mother and abruption of the placenta. Typically patients also have low platelets and can be at risk for stroke.

The second possibility is acute fatty liver f pregnancy which can also lead to fetal death and potential permanent liver damage.

I seriously recommend you consult with a physician or take her to the hospital immediately for evaluation... She needs her blood pressure checked, a urinalysis, a CBC with platelets, electrolyte including BUN/creatinine and a consultation with a high risk obstetrician. Sometimes the baby needs to be delivered prematurely to treat the mother.

I again am very concerned about your partners status and please consult immediately with a local physician and do not continue to try to diagnose her yourself. If she develops a severe headache or sees spots in front of her eyes she is at high risk of seizure and should go to the hospital immediately.

I am sorry to give you this answer to the question but I am glad you consulted with Healthcaremagic.com and I hope your partner gets the appropriate evaluation.

With best regards,

Dr. Brown
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What Causes Increased Levels Of Sgot And Agpt During Pregnancy?

Hello, and I hope I can help you today. Elevated liver enzymes and swelling unfortunately can be symptoms of two potentially very dangerous pregnancy complications. The first and most common is severe preeclampsia or HELLP syndrome which is a combination of hypertension, swelling and protein in the urine. It normally develops at term but if it does prematurely it can cause seizures in the mother and abruption of the placenta. Typically patients also have low platelets and can be at risk for stroke. The second possibility is acute fatty liver f pregnancy which can also lead to fetal death and potential permanent liver damage. I seriously recommend you consult with a physician or take her to the hospital immediately for evaluation... She needs her blood pressure checked, a urinalysis, a CBC with platelets, electrolyte including BUN/creatinine and a consultation with a high risk obstetrician. Sometimes the baby needs to be delivered prematurely to treat the mother. I again am very concerned about your partners status and please consult immediately with a local physician and do not continue to try to diagnose her yourself. If she develops a severe headache or sees spots in front of her eyes she is at high risk of seizure and should go to the hospital immediately. I am sorry to give you this answer to the question but I am glad you consulted with Healthcaremagic.com and I hope your partner gets the appropriate evaluation. With best regards, Dr. Brown