Hi! Good evening. I am Dr Shareef answering your query. If I were your doctor, I would go for a PET scan in this condition where biopsy came out to be negative. If need be I would go for a repeat biopsy from any other suitable site after a detailed clinical examination.
I hope this information would help you in discussing with your family physician/treating doctor in further management of your grandma's problem. Please do not hesitate to ask in case of any further doubts.
Thanks for choosing health care magic to clear doubts on your health problems. I wish your grandma an early recovery. Dr Shareef.

Hi,dear thanks for the query to my HCM virtual online clinic.Its my pleasure to help you .My diagnosis -Secondary mets in head, with femur mets necrosis, with mets in lung -which is related to breast cancer years ago.Negative test Cancer-report from the femur nodules-is due to the mets-necrosis.I am sure that this lump in the head and lungs and femur are metastatic lumps from the breast cancer of your grandma- few years ago.Still on safer side I advise you to Consult a ER Surgeon.Dont worry and act fast.This would solve your worrysome query.Hope this would solve your query.Wellcome to my HCM clinic once again.Have a Good Day.