The list of medications you are on (although quite long) is unfortunately what remains is the standard treatment for RA and also the biologicals like adalimumab that requires MTX to prevent autoantibody
You are quite right in thinking of Allergy with what seems to be rhinitis and occasionally allergenic triggers may become a problem in patients with autoimmune disorders
. It would be very helpful if you could remember at the time when the problems started 3 months, if there were any new medications introduced or changed to something else.
However, if I considered drug allergy the top of the list will be hydromorphone
that is an opioid analgesic
and can cause direct mast cell histamine release WITHOUT any allergy - specific antibodies. There is now a blood test available for those who want to exclude morphine allergy
, specific IgE against morphine. Pain killers can also cause direct mast cell degranulation and antihistamines are very helpful. Please see your doctor for an antihistamine prescription that needs to be used for 4-6 weeks after stopping the hydromorphone to see an effect.