hi, thank-you for providing the brief history of you. A thorough musculoskeletal assessment is advised. As you have knee pain, swelling of the feet and palm, this can be helped with physical therapy as for the other symptoms medication will be taken care by a physician. As due to increased creatinine, there leads to swelling as the kidney functioning is disturbed. So performing regular exercises will help imporve the venous return. also in my clinical experience I have seen patients with similar complaints and they respond to physical therapy well. for knee pain a thorough assessment is advised. Post which physical therapy will be helpful with the combination of drug therapy. Regards Jay Indravadan Patel