Hi, The choice of medication for microadenoma depends on the size and location of the tumor, as well as the individual patient s medical history and overall health. In general, the goal of treatment is to reduce the size of the tumor and alleviate symptoms caused by elevated levels of hormones. For microadenomas that secrete prolactin, which appears to be the case for your sister, medications called dopamine agonists are typically used. These drugs mimic the action of dopamine, a neurotransmitter that normally inhibits the release of prolactin. By stimulating dopamine receptors, dopamine agonists can suppress the production of prolactin and shrink the tumor. Some common dopamine agonists used for microadenomas include bromocriptine (Parlodel) and cabergoline (Dostinex). These drugs can have side effects such as nausea, dizziness, headache, and fatigue, but these are usually mild and transient. In the case of your sister, it seems that the medication she is taking to lower prolactin levels is causing chest pain and numbness on the left side. These symptoms should be reported to her doctor immediately, as they may indicate a serious adverse reaction to the medication. The dosage of the medication may be adjusted or it may be switched to a different medication. In addition to medication, your sister may benefit from regular monitoring of her hormone levels and tumor size, as well as lifestyle modifications such as stress reduction, exercise, and a healthy diet. She needs to work closely with her healthcare team to manage her multiple medical conditions and find the best treatment options that minimize side effects. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician