Hello, I understand your concern. Although there is not enough research and studies conducted on this matter, there have many reports to the FDA about a possible link between Depo Provera and colitis. The cause is unknown and the link has not been confirmed, because in order to do so, there has to be enough evidence. So until now, any link between the two is speculation based on personal experience. The best approach is, of course, to stop getting the depo shots and consider other forms of contraception, although, you must be aware that all forms of medical contraception carry a certain number of side effects. It is up to you and your doctor to decide what works best for you, while making sure it does not interfere with the treatment of colitis. The treatment of colitis consists of medicines and changes in your diet, but it mainly depends on the degree of the disease, which is to be determined by your doctor. Wishing you good health and all the best.