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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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It Occurred OHSS During IVF ,Please Suggest How To Reduce Chances Of OHSS ?

Hi, My wife underwent IVF on 10th December 2009. ER( Egg Retrieval) was successful on that day .18 oocytes were recovered .but after two days pain started in her lower abdomin area and started increasing .The ART Specilist stopped the procedure of ET(Egg transplant) as ultrasound confirmed OHSS(Ovarian Hyper Stimulation Syndrom) .Ovaries size had increased (B/L Ovaries enlarged and cystic ( rt ovary - 8 cm, lt ovary - 7 cm, free fluid ++ve)) . She was hospitalised for 3 days.Specilist suggested Periodic Ultrasound . FET(Frozen Embryo Transplant) was planned after 2 months.After two montys no ET was done, as the thawed embryos were not of good quality as per the specialist (Embryos frozen : 4 (Grade 1A/2B)) . Medicine Suggested presentlly is Metformin- 1500mg, folic acid, colsprin - 75 mg. (These continued through out). Second cycle of IVF suggested from next day 2 . Some details: 1. Female Age : 31 2. Height : 173cm 3. Weight : 70 4. Reason of Infertility : PCOD (Polycystic Ovarian Disease), 5. Have you had any pelvic surgery? yes 6. Surgery Name : Adhesiolysis( Ovarian Drilling Done on both sides) (Year : 2006) 7. Findings : Both ovaries polycystic, fallopian tubes open 8. Medical problems and current medications of female partner: Suspected uterine Tuberculosis, had ATT (AKT - 2 / 4)medicines for 6 months. 9. In vitro fertilization (IVF) : yes Date : 10 Dec 2009 Stimulation Protocol : D21 onwards : Lupride 1/2 cc (14/11/09 to 8/12/09 (23 inj)), GonalF 225 ml (1/12/09 to 4/12/09 (4inj)), HCG ( 8/12/09 at 1 o clock at night) Dose of Hmg :300 Days of Hmg :D5,6,7 (5/12/09 to 7/12/09) Follicles grown :18-20 Eggs collected :15 (10/12/2009) Embryos formed :4 Embryos transferred :0 Embryos frozen :4 (Grade 1A/2B) My Question : 1. Is it possible that OHSS may reoccur? Spl suggests that if procedure starts on D2, probability reduces by 20%. 2. Is the body ready for 2nd IVF so soon? 3. I want to reduce chances of OHSS. Please suggest how to go about it.
Mon, 18 Jul 2011
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  Anonymous's Response
's  Response

It is a common side effect forth eovulation induction drugs i guess, co seven my wife had to face the OHSS when we weretaking infertility treatment..now she is fine and we are expecting to have our baby in another 3 months time..Follow what her doctor decieds to do..in case of doubts, go in for a second opinion to clear your doubts..

  User's Response
Dr. Varsha Khose's  Response
Hi, well the cause of OHSS is overstimulation.The doctor may give your wife a low dose of stimulation injections this time.Ask your wife to take lots of protiens during ivf treatment.Also the age , built plays role in OHSS.It is sad that this makes your all efforts go in waste but the only way to avoid it is give less stimulation which means you may end up getting less eggs on the day of egg pick up and thus less embryos but as you know even a single good embryo is sufficient to hit the pregnancy so ask your doctor to consider less use of stimulation injection drug dose.
For any further assistance you may write me on drvarshakhose@gmail.com.I am working with one of the wellknown ivf specialist in the mumbai who has a very good success rate in ivf

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It Occurred OHSS During IVF ,Please Suggest How To Reduce Chances Of OHSS ?

It is a common side effect forth eovulation induction drugs i guess, co seven my wife had to face the OHSS when we weretaking infertility treatment..now she is fine and we are expecting to have our baby in another 3 months time..Follow what her doctor decieds to do..in case of doubts, go in for a second opinion to clear your doubts..