Hi, Oncotrex is a brand name for methotrexate, which is a medication used to treat psoriasis and certain types of cancer. Maxepa is a brand name for omega-3 fatty acid supplements. Folvite is a brand name for folic acid, which is a vitamin supplement. Methotrexate can have potential side effects such as liver damage, lung problems, decreased immunity, and increased risk of infections. Long-term use of methotrexate requires careful monitoring by a healthcare professional, including regular blood tests to check liver function, kidney function, and blood cell counts. Omega-3 fatty acid supplements like Maxepa are generally considered safe for long-term use, but some people may experience side effects such as upset stomach, diarrhea, and fishy aftertaste. Folic acid is a vitamin that is generally considered safe for long-term use. It s important to continue taking your medications as prescribed by your healthcare provider and to report any new or concerning symptoms to them. They can monitor you for any potential side effects and adjust your treatment plan as needed. If you have concerns about the safety of your medications, you can discuss them with your healthcare provider. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician