Hello You mentioned that your brother is having TUBERCULOSIS from last three years and he is taking treatment off & on i.e in a haphazard manner . When such patient visit my clinic I at once advise X RAY chest PA view, blood for C B C, E S R ( it is very high in this type of cases , even 100 mm 1st hour) , sputum for a A F B . First of all keep this record at safe place . This is because your brother has developed a type of tuberculosis known as MULTI DRUG RESISTANT TUBERCULOSIS ( M D R T ). Since treatment is from 3 years ,now you have to take this treatment for 30 months ( 2 1/2 years ) regularly ( even not allow to stop single day ). Assuming that the weight of your brother is 50 kg , I am prescribing this treatment . 1 Injection Capreomycin 750 -1000 mg / day for 3 months . 2 Tablet ehionamide or prothionamide 250 mg one tablet twice in day for 2 1/2 years . 3 Capsule cycloserine 250 mg twice in day for 2 1/2 years . 4 Tablet levofloxacin 750 mg in the night ( one / day ) for 2 1/2 years . If your brother can tolerate ( show no untoward effect ) then start 5 Pyrazinamide 750 mg twice in day for 2 1/2 years. Because these are so many drugs so it is bound that patient will develop nausea and vomiting so I add antacid syrup 4 TSF twice in day + pantaloc-D twice in day. This is my own practical experience and also a standard treatment for M D R T cases. But keep one thing in mind , if your brother will stop this treatment intentionally than there it will be very very difficult to treat in future. Since all these drugs are prescription drugs , so consult a physician and get his prescription . Hope if you start this treatment , please think twice before this . Good luck.