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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Have Been Diagnosed With Richters Syndrome After Having CLL. Have Tumours One Kidney And Pump One Lung. Weak To Start Chemo. Trying Chemo Could Kill?

My mom was just diagnosed with Richter's Syndrome after having CLL for 3 years. She kept getting sicker and sicker with CLL fluid in her lungs from enlarged lymph nodes in her chest. I had her flown by ambulatory jet to MD Anderson where they made the diagnosis. She has tumors all over one kidney (they put a tube in to bypass that) and she has a pump in one lung. They want to start chemo but she is so weak. My question is, is there anyway for her to overcome this and should she even try the chemo at this point, could it kill her?
Sat, 6 Jul 2013
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General & Family Physician 's  Response
Hello,
Thanks for the query to H. C. M. Forum.
After chronic leukoid leukaemia , Richter syndrome is common and there is increase in lactate dehydrogenase level with enlargement of most of lymph nodes.
Now your query is ,whether your mother will tolerate chemotherapy or not as , she is weak.
Chemotherapy tolerance is not depends upon weakness but it depends upon certain parameters as total leucocytes count, platelets count, red blood cells count, anemia.
If all these are within normal limit , they can start chemotherapy .
2nd point is treating doctors will decide the chemotherapy.
Hope I have answered your question.
I further any question I will help.
Dr. HET
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Have Been Diagnosed With Richters Syndrome After Having CLL. Have Tumours One Kidney And Pump One Lung. Weak To Start Chemo. Trying Chemo Could Kill?

Hello, Thanks for the query to H. C. M. Forum. After chronic leukoid leukaemia , Richter syndrome is common and there is increase in lactate dehydrogenase level with enlargement of most of lymph nodes. Now your query is ,whether your mother will tolerate chemotherapy or not as , she is weak. Chemotherapy tolerance is not depends upon weakness but it depends upon certain parameters as total leucocytes count, platelets count, red blood cells count, anemia. If all these are within normal limit , they can start chemotherapy . 2nd point is treating doctors will decide the chemotherapy. Hope I have answered your question. I further any question I will help. Dr. HET