Hello, Thanks for writing your query to us. Blood pressure & diabetes both can affect the kidney function. Hence it is very important that both blood pressure as well as sugar levels should be kept with in normal range. S.creatinine increasing from 4.6 to 5.5 is a very significant finding. It suggests that his kidney s are getting weak day by day. Whatever damage has occured that cannot be completely cured but we need to restrict or decrease any further damage to his kidneys. Consult a Nephrologist in your area & show you dad to him along with all his reports. Take care.