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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Do I Have Primary Hyperparathyroid?

Hello I have added my details below, can you tell me if this is primary hyperparathyroid or something else ?

Age - 23, male
Computer programmer - 8-10 hrs/day, don't go out in the sun

Past history
Following a low carb vegan diet 2-3 years (no dairy sources in the diet)
irritable bowel syndrome
Seizure around age 9-10

Symptoms
obvious - muscle weakness, osteopenia
subtle/occasional - memory problems, general weakness, anxiety, problems passing urine(no urine problems currently)

1st blood test (from Lab company A)

Calcium 11 mg/dl (8 - 10.5)
Potassium 5 nmol/L (3.5-5.5)
Serum iron 101.0 ugm/dl (59 - 158)
Total iron binding capacity 303 ugm/dl (274-385)
Vitamin D 25 Hydroxy 3.42 ng/ml (> 30 ng/ml)
Alkaline Phosphatase 353 U/L (108-306)

Next day (From lab company A)
Calcium ionized 4.8 mgm/dl (4.0 - 4.8 mgm/dl)
serum magnesium 1.8 (1.70 - 2.70)

I think after 1st blood test I took 2 small vitamin D supplements
which had 200 IU units in each and calcium citrate of 1000 mg.
I took it even before I got the lab results.

I had an 4-5 month old liver function test report which had
Alkaline phosphate 136 units/l (39-117)

2nd Blood test the very next day (From lab company A which outsourced my blood to company B)

PTH, intact 150 (10-65) pg/ml
Calcium 12 (8.5 - 10.3) mg/dl

Endo doctor said Lab A and B might be wrong, so let's check it again after 1 week.

3rd Blood test (From lab company C) after 1 week

Calcium, Serum 10.02 mg/DL (8.10 - 10.40)
Calcium, ionized 1.26 nmol/L (1.16 - 1.32)
PTH, intact 103.80 pg/DL (15.00 - 68.00)

After this test I think I ate some dairy products like milk, eggs etc

4th Blood test (From Lab company C) after 2 weeks

PTh 61.20 pg/ml (15-68)
Calcium, Serum 10.48 mg/DL (8.10 - 10.40)
Calcium, ionized 1.28 nmol/ (1.16 - 1.32)
Alkaline Phosphate 119.00 U/L (30 - 120)
Phosphorus 5.00 mg/DL (2.70 - 4.50)

Sodium 140 meg/L (137-150)
Potassium, serum 4.30 meq/l(3.50-5.30)
Chloride, serum 103 meq/l (99 - 111)

5th blood test today (From Lab company C)

Vitamin D, 25 hydroxy 28.80 nmol/L (> 75 nmol/L)
converts to 11.53 ng/ml (>30 ng/ml)

Phosphorus, serum 4.66 mg/DL (2.70 - 4.50)
Potassium, serum 4.30 meq/l (3.50- 5.30)
Magnesium serum 2.00 mg/dl (1.80 - 2.60)

Other tests:

Calcium, 24 hours urine 85.50 (100-300) mg/24 hrs
total volume 4500 (800-1800) ml/day

Sestamibi scan = negative

Complete Haemogram

Haemoglobin 13.5 gm% (13 - 17)
Total leucocyte count 5800 /cumm (4000- 11000)

Different Leucocyte count

POlymorphs 63 % (40 -80)
LYMPHOCYTES 31 % (20-40)
EOSINOPHILS 05 % (1-6)
MONOCYTES 01 % (2-16)
BASOPHILS 00 % (1-2)
RBC 4.19 million/cumm (4.50 -5.50)
platelet count 193000 /cumm (150000 - 450000)
pcv 39.1 % (40-50)
mcv 93.4 femto litres (83-101)
mch 32.2 pico grams (27-32)
MCHC 34.5 G/DL (31.5 - 34.5)
ESR (We stergren) 05 mm/1 hr (5-30)

Peripheral Smear

RBC series RBCs are normocytic normochromic
WBC series TLC, DLC Within normals limits NO immature cells seen
PLatelets Platelets are adequate
Haemoparasites No haemoparasites seen
Opinion Peripheral blood picture is unremarkable

Liver function test:

Total protein 7.34 g/dl (ref range 6.0 - 8.4)
albumin 4.67 g/dl (ref range 3.5 - 5.5)
globulin 2.67 (1.20 -1.60)
a/g ratio 1.75 (ref range 1.20-1.60)
total bilirubun 0.53 mg/dl (0.10 - 1.20)
conjugated bilirubin 0.27 mg/dl (0 - 0.70)
unconjugated bilirubin 0.27 mg/dl (0 - 0.70)
sgot (ast) 17 u/L (5-34)
alk phosphatas 119 U/L (53-128)
gamma gt 18 u/L (12-64)

Lipid profile

Cholestrol 136 mg/dl (ref range 140 -220)
TRIGLYCERILE 70 MG/DL (20 -150)
HDL - CHOLESTROL 39 mg/dl (30 - 65)
LDL CHOLESTROL 85 mg/dl (0-130)

(calculated parameter)

VLDL CHOLESTEROL 14 mg/dl (ref range 5 -40)
LDL / HDL RATIO 2.18 (0 - 3.55)
CHOL/ HDL RATIO 3.49 (0 - 4.97)

Biochemistry

Blood sugar fasting 91 mg/dl (ref range 70 -110)
urine sugar fasting N.R

Blood sugar PP 95 mg/dl (ref range 80 -140)
urine sugar PP N.R

Blood urea 17 mg/dl (17 -55)
serum creatinine 0.65 mg/dl (0.30 -1.30)
uric acid 4.73 mg/dl (3.50 - 7.20)

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Thu, 3 Jul 2014
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Pathologist and Microbiologist 's  Response
Hi,
Going through your report, I initially found few reports of hypercalcemia, which returned to normal. Only consistent reports were hyperparathyroidism and low Vit D levels.
Looking at these values, I think the Parathyroid hormone is being produced excessively to balance the calcium.
You need to take Vit D medications to increase the levels.
As you did not find any adenomas in sestamibi scan, it points towards secondary hyperparathyroidism.
Vit D deficiency could have led to hypocalcemia triggering increasing increase parathyroid hormone levels. Now in response, you are finding mild hypercalcemia.
Any further queries, happy to help again.
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Do I Have Primary Hyperparathyroid?

Hi, Going through your report, I initially found few reports of hypercalcemia, which returned to normal. Only consistent reports were hyperparathyroidism and low Vit D levels. Looking at these values, I think the Parathyroid hormone is being produced excessively to balance the calcium. You need to take Vit D medications to increase the levels. As you did not find any adenomas in sestamibi scan, it points towards secondary hyperparathyroidism. Vit D deficiency could have led to hypocalcemia triggering increasing increase parathyroid hormone levels. Now in response, you are finding mild hypercalcemia. Any further queries, happy to help again.