Hello, * There is no role of simethicone in diarrhoea with IBS. * Additional guidelines for best relief - drink more liquids as possible in form of boiled water, lemon juice, coconut water, buttermilk - strict dietary measures to avoid all spices, non-veg, junk items - probiotics with lactobacillus with homemade fresh yoghurt - avoid stress, anxiety (major provokers of GI hypermotility) - avoid smoking, alcohol if consuming - prescription of antibiotic as metronidazole or Rifaximin serve best in the majority of the cases with an acute flare-up. - the need for specific IBS modifying drugs as sulfasalazine, Mesacol or else, need clinical assessment. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Bhagyesh V. Patel, General Surgeon