Hi

Thanks for the query

Yes, Lamotrigine and pregabalin are effective antiepileptics and seem to have been effective in your case .

The twitching and numbness that you are experiencing can be the "sensory phenomena" associated with simple partial seizure (SPS) getting converted to complex partial seizure (CPS).

Dejavu experience is usually associated with CPS

The experience that you are labeling as dejavu, are you sure ?, if not can you describe it ?

Sometimes multiple seizure types can coexist, can follow one after other, can transform one form to other in due course, this does not mean that the antiepileptics that you are taking are not effective for controlling your seizure.

Or else, for some reason, if you have discontinued the drug for some period or you have resumed smoking or increased smoking, or taking some particular drugs (that interact with lamotrigine or pregabalin) can decrease the drug level in the body producing the symptoms back.

If you are exposed to seizure precipitants like sleep deprivation, stress etc, the symptoms can be back

If no above-described factors are identified, usually, doctors increase the dose of the antiepileptic drugs, if tolerated.

But, because treating seizure disorder needs very careful detailed history taking, detailed neurological examination and if needed, EEG and neuroimaging, electrolyte assessment like calcium and magnesium; and is a serious business; and is a chronic treatment, it would be unfair to come to a conclusion on my part from such a small description.

I must recommend you to see your treating neurologist and discuss all the possibilities and take a decision, but do not panic.

Hope I have answered your query. I will be available for further clarifications.

Wish you a speedy recovery and good health.

Regards.

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