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Is High Dose Of Wellbutrin Safe?

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Posted on Wed, 12 Mar 2014
Question: I have been feeling the best ever, when taking 600mg of wellbutrin & 400mg of lamictal, for my bipolar 2 disorder as well as my ocd. I have been on 400mg of both for 8 years with no side effects, so why do people say 600mg is unsafe?
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Answered by Dr. Jorge Brenes-Salazar (1 hour later)
Brief Answer: Unproven risk of arrhythmias Detailed Answer: Dear patient, Thanks for the query. I am glad you are feeling so great, Bipolar can be tough at times! There have been scattered reports about Wellbutrin increasing an electrical interval of the heart, called QT, that may theoretically predispose to abnormal rhythms of the heart; the FDA has not issued a black box warning and I have not seen it in clinical practice, so if you are stable from a psychiatric standpoint, I would not change the dose. You should run it by your Internist or Family doctor that knows you best for sure. Hope this helps wish you the best, Dr Brenes-Salazar MD Mayo Clinic MN Cardiology
Note: For further guidance on mental health, Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Dr. Jorge Brenes-Salazar

Cardiologist

Practicing since :2007

Answered : 1198 Questions

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Is High Dose Of Wellbutrin Safe?

Brief Answer: Unproven risk of arrhythmias Detailed Answer: Dear patient, Thanks for the query. I am glad you are feeling so great, Bipolar can be tough at times! There have been scattered reports about Wellbutrin increasing an electrical interval of the heart, called QT, that may theoretically predispose to abnormal rhythms of the heart; the FDA has not issued a black box warning and I have not seen it in clinical practice, so if you are stable from a psychiatric standpoint, I would not change the dose. You should run it by your Internist or Family doctor that knows you best for sure. Hope this helps wish you the best, Dr Brenes-Salazar MD Mayo Clinic MN Cardiology